Home | FAQ

FAQ

Find an question

Type

Services

The CDMO/CMO division of Ennolys is a Lesaffre business unit with over 30 years in industrial fermentation, based in Soustons, France. It offers more than 200,000 liters of fermentation capacity (vessels from 100 L to 50,000 L) and an integrated offering covering fermentation (USP), purification (DSP), drying (lyophilization, spray-drying), and quality management (FSSC 22000, ISO 9001). It supports biotech, foodtech, and industrial companies from pilot stage through commercial production, across a wide range of microorganisms (bacteria, yeasts, filamentous fungi, microalgae).

Services

In Europe, regulation is not an end-of-project formality. It structures the process. Depending on the target application (food, nutraceutical, cosmetic, agriculture), regulatory frameworks differ — Novel Food, additives, enzymes, GMOs — with specific requirements on product identity, specifications, and process consistency. Integrating regulatory strategy from the beginning of scale-up avoids costly rework and delays at market authorization.

Services

The choice depends on the tradeoff between control, cost, flexibility, and risk. In-house production offers maximum control but requires significant CAPEX. Toll manufacturing/CMO works when the process is already locked and the need is purely production capacity. A CDMO combines development and manufacturing: it supports the project from technology transfer through commercial production, with process development support. For biotech and foodtech companies without their own industrial infrastructure, it’s often the fastest route.

Services

DSP can account for a significant share of production costs and overall yield loss. The higher the required purity, or the longer the purification train, the greater the risk. A purification strategy that works in the lab is not necessarily scalable, transferable to a CDMO, or economically viable at production scale. DSP must be designed as a process pillar from the outset — not added downstream.

Services

The key challenges include oxygen and mass transfer (critical in aerobic fermentation), mixing gradients in large volumes, batch-to-batch reproducibility, industrial operational constraints (CIP/SIP, contamination prevention), and a consistently underestimated downstream processing component. The most common errors are scaling before product specs are finalized, deferring DSP design, and selecting an industrial partner without validating equipment compatibility.

Services

Fermentation scale-up is the process of moving a microbial process from laboratory conditions (a few liters) to industrial production (tens of thousands of liters). It’s not simply a volume increase. It involves making the bioprocess robust, reproducible, and controllable, while managing quality, regulatory compliance, and production costs. Scale-up covers fermentation itself (USP), downstream processing (DSP), and when the final product is a powder, drying processes (lyophilization, spray-drying).

Sales

Yes. We support our clients with tailored flavor solutions: development of a specific molecule, adjustment of the sensory profile, formulation, regulatory or technical adaptation. Our R&D and marketing teams work closely with you.

Career

Proficiency in English is an asset, especially for internationally oriented positions (R&D, export sales…). However, many roles are accessible with fluent French only.

Sales

Ennolys is a Business Unit of the Lesaffre group, a global player in fermentation. This connection gives us access to an international network, advanced R&D tools, and a strong corporate culture, while maintaining a human scale and local autonomy.

Career

You can view our job offers on the Lesaffre group’s recruitment platform. Spontaneous applications are also possible via our contact form under the “Recruitment” category.